LTP enhances synaptogenesis in the developing hippocampus

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LTP enhances synaptogenesis in the developing hippocampus

In adult hippocampus, long-term potentiation (LTP) produces synapse enlargement while preventing the formation of new small dendritic spines. Here, we tested how LTP affects structural synaptic plasticity in hippocampal area CA1 of Long-Evans rats at postnatal day 15 (P15). P15 is an age of robust synaptogenesis when less than 35% of dendritic spines have formed. We hypothesized that LTP might ...

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ژورنال

عنوان ژورنال: Hippocampus

سال: 2015

ISSN: 1050-9631,1098-1063

DOI: 10.1002/hipo.22536